Our Services

Drug Discovery
We provide a wide range of services to support academic research and pharmaceutical companies from the earliest stages of drug discovery and development process

Molecular Modelling
Design of drugs and/or bioactive molecules selective vs specific enzymes
Docking-based virtual screening of chemical libraries (freely accessible, commercially available and in-house developed)
3D comparative modeling of small enzymes and protein complexes
3D modeling of protein-protein interactions
3D modeling of protein-nucleic acid interactions
3D modeling of protein-ligand interactions
Antibody design and 3D modeling of Antibody/Antigen/Receptor interactions
Set-up of ab initio approaches for the study of the protein folding

Cytotoxicity assays
Cell viability
Cytotoxicity kinetics
Spheroid kinetics

Investigation of mechanisms of action
Cell cycle
Western blot
Apoptosis assays
ROS levels determination

Bioinformatics Analysis
The analysis of data produced during Next Generation Sequencing experiments requires a peculiar mix of expertise, including Biology, Informatics, Statistics and Maths. Next Generation Sequencing techniques allow the gathering of a wide range of information about an individual, but these data need to be accurately filtered and interpreted.

Bioinformatics data analysis is needed to process these raw information, in order to provide clinicians with a narrow set of relevant data to better understand the starting biological question, and possibly answer it efficiently.

Sequencing
Sequencing is a technique that allows to “read” the DNA composition of an individual, in order to collect a set of genetic information, useful to assess the person’s health condition and to cure diseases.

The most recent sequencing techniques are called Next Generation Sequencing (NGS), and provide a wide and deep genome analysis, which can be of different types depending on the biological problem to investigate.

The classic Sanger sequencing, instead, is not as massive as NGS, but is used to analyse specific genomic regions and to validate NGS data analysis results.

Counselling
Designing and performing biological experiments can be daunting, and if not conceived correctly, can provide wrong and harmful results.

An accurate knowledge of the starting biological question and of specific techniques to face it is fundamental. Our experts are available to help you plan and perform successfully many kinds of scientific projects.

 For info or quotations, please write at info@browser-bioinf.com